Vav proteins, adaptors and cell signaling

Vav Proteins Regulate the Plasma Cell

Vav proteins regulate peripheral B-cell survival.

Mice lacking all 3 Vav proteins fail to produce significant numbers of recirculating follicular or marginal zone B cells. Those B cells that do mature have shortened lifespans. The constitutive nuclear factor-kappaB (NF-kappaB) activity of resting naive B cells required Vav function and expression of cellular reticuloendotheliosis (c-Rel). Rel-A was reduced in Vav-deficient B cells. Furthermore...

Adaptors and Molecular Scaffolds in Immune Cell Signaling

containing leukocyte protein of 76 kDa), BLNK (B cell linker protein)/SLP-65 (SH2 domain–containing leuko-cyte protein of 65 kDa), FYB (Fyn T-binding protein)/ SLAP (SLP-76-associated protein), SKAP55 (Src kinase– associated protein of 55 kDa), and the 3BP2 protein. Introduction Positive Adaptors in T Cells The antigen receptors on T and B lymphocytes (TCR and Following their activation by TCR ...

Vav family proteins couple to diverse cell surface receptors.

Vav proteins are guanine nucleotide exchange factors for Rho family GTPases which activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. Vav proteins contain several protein binding domains which can link cell surface receptors to downstream signaling proteins. Vav1 is expressed exclusively in hematopoietic cells and tyrosine phosphorylated in response t...

Lymphocyte signaling: Adapting new adaptors

New developments in lymphocyte signaling have revealed insights into the proximal phosphorylation events associated with the T-cell receptor and into the importance of the T-cell adaptor protein Slp-76 and its B-cell homolog in the transduction of the signal from the antigen receptor.